Scientist/Staff Scientist, Formulation Development

Recruiter
Regeneron Pharmaceuticals
Location
Tarrytown
Salary
Competitive
Posted
Aug 13, 2017
Closes
Aug 15, 2017
Industry
Chemical
Employer Type
Direct Employer
Employment Type
Permanent
Hours
Full Time
Position Summary

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary:

The Scientist/Staff Scientist in the Formulation Development Group (Tarrytown, NY) is responsible for antibody based drug product design and development in various stages. The Scientist carries out research on protein drug delivery (i.e. controlled or sustained release, delivery devices) and drug targeting for parenteral and enteral routes of administration, protein formulation, protein stability and characterization, and new technology development for high concentration product development.

Job Responsibilities:

* Leads and participates in formulation and product development and stability assessment activities that may include candidate screening and selection, developing lyophilized, spray dried, or liquid formulations for preclinical and Phase 1 clinical studies, and developing liquid formulations for Phase 2/3 clinical studies and commercialization.

* Responsible for identifying, evaluating, and developing novel delivery systems (i.e. controlled or sustained release) and device technologies suitable for protein, peptide, or nucleic acid delivery (i.e. combination products)

* Develops fit-for-purpose analytical methods to support formulation and process development and research stability testing

* Independently designs stability studies and in vitro experiments to understand quality attributes to support formulation development and optimization. Primarily responsible for executing experiments at the bench, performing subsequent data analysis, and documenting all work.

* Presents work at group, department and cross functional meetings, serves as a team representative in drug development team meetings, and shares knowledge and expertise of formulations development at cross-functional team meetings

* Authors and reviews formulation development sections of regulatory and technical documents, study reports and technology transfer documents

* Participates in general lab and instrument maintenance

* Adept at learning about and assessing new technologies in formulation, devices, and analytical methods

* Able to handle multiple tasks while meeting timelines and adapting to changing priorities

Job Requirements:

* Ph.D. in Chemistry, Biochemistry, Pharmaceutical Science, Chemical or Biomedical Engineering (or related discipline), Materials Science with 0-7 years of relevant industry experience, and a proven track record of publications in the field. Post-doctoral experience is preferred but not a requirement.

* Must have experience with controlled release delivery systems, such as micro/nanoparticles, hydrogels, polymers, liposomes, devices, etc., and preferably with proteins, peptides, or RNA/DNA.

* Experience in spray drying, microfluidics, particle engineering, or polymer synthesis and characterization is highly desirable

* Background in combination device development or mechanical engineering is preferred

* Excellent oral and written communication skills are required.

* Demonstrated track record of publications or patents

* Should be detail oriented, be able to recognize subtle trends in data, good problem solving abilities, and possess an ability to grasp the big picture.

* Enthusiasm in science with a motivation for making contributions in a team environment is necessary.

* Background in protein characterization, protein stability, analytical method development, admixture compatibility study, lab automation and parental drug product process development is highly desirable.

* Hands-on experience and trouble-shooting proficiency with applying chromatographic (HPLC, UPLC, column chromatography), capillary electrophoresis and/or biophysical techniques (UV-vis, DLS, CD, FTIR, DSC, AUC, Fluorescence, Raman spectroscopy, particle analysis, GPC, etc.) for protein characterization are plus.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

Requisition Number: 10279BRPosted by StartWire