Postdoctoral Associate - 3D Chromatin Genomics - Ruan Lab

Jackson Laboratory
Oct 14, 2016
Oct 19, 2016
Employer Type
Direct Employer
Employment Type
Full Time
Tracking Code
Job Description

**POSITION TITLE:** **Postdoctoral Associate**

Three-Dimensional (3D) Chromatin Genomics - JAX 4D Nucleome Center

**Supervisor: Dr. Yijun Ruan, Principal Investigator**



The JAX 4D Nucleome Center is seeking enthusiastic, highly-skilled computational and experimental postdocs to develop computational and genomic approaches for understanding 3D genome biology under the light of diverse genomic and genetic information.

Investigators at the JAX 4D Nucleome Center at The Jackson Laboratory for Genomic Medicine have pioneered technologies for the genome-wide profiling of chromatin interactions; the 3D structure of these interactions plays a major role in regulating gene expression by bringing together regulatory elements that appear distal on the linear genome.

**Working under the supervision of Principal Investigator Yijun Ruan, successful applicants to this position will be developing projects aligned with Dr. Ruan's research focus. For details about Dr. Ruan's areas of focus, visit The Ruan Lab.**


The Center's postdoctoral researchers will be generating and analyzing human chromatin interaction datasets in integration with other genomics and genetics datasets. We are seeking self-motivated, independent individuals who are interested in building their own career paths; however, postdoctoral fellows are expected to coordinate with and report to the PI responsible for the research areas addressed by their project.

The fellows will develop research projects in one or more areas of focus:

* ?3D genome mapping and imaging technologies
* Application of nano-engineering toward genomic methodologies
* Computational modeling of 3D genome architectures
* Building regulatory networks at multiple layers including gene expression, epigenetic, and chromatin data
* Integrating regulatory interactions with genetic data
* Mining and aligning chromatin interaction datasets in diverse human cell types
* Functional perturbation of topological elements


The JAX 4D Nucleome Center is interdisciplinary and collaborative, and preference will be given to individuals with experience working in such an environment.

For computational postdocs desired attributes include:

* Familiarity with next generation sequencing data sets and pre-processing
* PhD in a statistics/biostatistics or another computational field (CS, EE, Physics) with a strong foundation in statistics and data analyses
* Excellent programming skills, preferentially with expertise in R and/or python and UNIX programming
* Familiarity with network building, mining, alignment algorithms
* Familiarity with bioinformatics resources, i.e., UCSC genome browser, NCBI

For experimental postdocs desired attributes include:

* Strong problem-solving skills, creative thinking, and enthusiastic about science
* Familiarity with next generation sequencing data sets and data generation
* PhD in a genomics/genetics/biology or another relevant field
* Excellent communication skills and fully fluent spoken and written English
* Expertise in cellular and molecular biology techniques


Although the genome is typically thought of as a linear sequence, it is actually a dynamic three-dimensional structure. Gene loci and regulatory elements that are linearly distant-or even on separate chromosomes-may be brought in spatial proximity, and such interactions are of fundamental importance for understanding genome regulation. The ultimate goal of the JAX 4D Nucleome Center is to deliver a Nucleome Positioning System for the generation of complex chromatin interaction network maps in the context of 3D genome structures. Such maps will be used to monitor and reference the dynamics of individual genomic elements, providing context to better understand gene function and the effects of genetic variation on gene function. The scientific team is led by Yijun Ruan, Chia-Lin Wei, Jeff Chuang, and Duygu Ucar.

The four major scientific goals of the JAX 4D Nucleome Center are to:

* Develop and improve technologies for high-resolution and haplotype-specific 3D mapping.
* Refine an integrative and comprehensive data-analysis platform (3D-NOME) for the study of nuclear architecture.
* Elucidate the spatiotemporal regulation of 3D genome organization and function in human cells.
* Use nuclear imaging and genome editing to structurally and functionally validate the 3D maps and predictions of regulatory interactions developed by the center.


To be considered for this postdoctoral opportunity, please complete the online application and upload a single pdf document that contains: 1) a cover letter, 2) a full CV with a complete list of publications, 3) contact information for three references, and 4) a list of laboratory methods and computational skills mastered.

**EEO:** The Jackson Laboratory is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Job Location
Farmington, Connecticut, United States
Position Type
Full-Time/Regular da6bba58b43c4fd9a4ec3a2ba38de6b5